Infection with orf virus is usually confined to the epidermis (top layer) of the skin. Lesions (one to a few) or nodules will often occur on the fingers, hands, or the forearms. Lesions begin as small papules that will become ulcerative in nature. Orf virus lesions typically progress through six stages each lasting … See moreOrf virus infections in humans typically occur when broken skin comes into contact with the virus from infected animals or contaminated equipment. Activities that may put you at risk for infection include: 1. … See moreCurrently there is no approved treatment for an orf virus infection. However, the lesion can become infected with bacteria if not properly managed. The lesion should be kept dry and … See moreA laboratory test for orf virus in people is available at the Centers for Disease Control and Prevention (CDC). Specimens must be submitted for testing through a doctor or health department. See morePeople can become infected with orf virus by having direct contact with infected animals or through equipment contaminated with the virus. Some animals may or may … See more

After incubation of 3-7 days, the orf infection goes through six clinical stages, each lasting about 1 week, as follows: Stage 1 (maculopapular) - A red elevated lesion (see the image...

The progression of Orf from infection to resolution has been categorized sequentially into six stages each stage taking roughly one week. Citation 1 The first stage of ORFV infection is termed as the maculopapular stage which is distinguished by vacuolization of the cells of the upper epidermis.