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Popular Questions
What is the main idea of Federalist? Federalists battled for adoption of the Constitution They favored weaker state governments, a strong centralized government, the indirect election of government officials, longer term limits for officeholders, and representative, rather than direct, democracy.
What did the Federalists party believe in? The party favored centralization, federalism, modernization, industrialization and protectionism. Washington, D.C. The Federalists called for a strong national government that promoted economic growth and fostered friendly relationships with Great Britain in opposition to Revolutionary France.
What is being a Federalist? Those who supported the Constitution and a stronger national republic were known as Federalists. Those who opposed the ratification of the Constitution in favor of small localized government were known as Anti-Federalists.
Who were the 3 leading Federalists? A collection of the writings of Alexander Hamilton, John Jay and James Madison during 1787-88. These papers lay out the ideology of the federalists during the creation of the U.S. Constitution.
How does Hotair regulate gene expression? HOTAIR can act through promoting the chromatin relocalization done by PRC2. This targeting of PRC2 in the genome leads into a distinct pattern of gene expression necessary for breast cancer progression21,35. Specifically, an overlap exists between HOTAIR-binding motif and BRCA1-binding region in EZH2.
How does Hotair exert its function? HOTAIR has been shown to function as a key regulator of chromatin states and dynamics by binding to the specific chromatin modification complex polycomb repressive complex 2 (PRC2), thereby recruiting and affecting PRC2 occupancy on genes genome-wide [2, 3].