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The New England Journal of Medicine: Research & Review Articles on Disease & Clinical Practice
The New England Journal of Medicine (NEJM) is a weekly general medical journal that publishes new medical research and review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.
https://www.nejm.org/
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The New England Journal of Medicine (NEJM) is a weekly general medical journal that publishes new medical research and review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.
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  1. Neoadjuvant Cemiplimab for Squamous-Cell Carcinoma
  2. Colonoscopy Screening and Risks of Colorectal Cancer and Related Death
  3. DHA in Preterm Infants and IQ at 5 Years
  4. BP Targets in Comatose Cardiac Arrest Survivors
  5. Ruxolitinib Cream for Vitiligo
  6. Oxygen Targets in Cardiac Arrest
  7. Intermittently Scanned Continuous Glucose Monitoring for Diabetes
  8. PCI for Ischemic Left Ventricular Dysfunction
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  1. New England Journal of Medicine
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  73. Neoadjuvant Cemiplimab in Squamous-Cell Carcinoma
  74. Examining Medical Malpractice Law
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  76. A Shear Decline
  77. Current Issue
  78. Current Issue
  79. October 27, 2022  Vol. 387  No. 17
  80. October 20, 2022  Vol. 387  No. 16
  81. October 13, 2022  Vol. 387  No. 15
  82. October 6, 2022  Vol. 387  No. 14
  83. Browse full issue index
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  86. Protection against Omicron from Vaccination and Previous Infection in a Prison System  E.T. Chin et al.
  87. Monkeypox  A. Gessain et al.
  88. Haloperidol for the Treatment of Delirium in ICU Patients  N.C. Andersen-Ranberg et al.
  89. Early Mobilization of Critical Care Patients — Still More to Learn  M. Moss
  90. Early Active Mobilization during Mechanical Ventilation in the ICU  The TEAM Study Investigators and the ANZICS Clinical Trials Group
  91. Improved Protocols for Ventilator Liberation  C.C. Hardin
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  114. Advanced Search
  115. https://www.nejm.org/doi/full/10.1056/NEJMoa2208375?query=featured_home
  116. Original Article
  117. Colonoscopy Screening and Colorectal Cancer M. Bretthauer and Others In this randomized trial involving 84,585 participants in Poland, Norway, and Sweden, the risk of colorectal cancer at 10 years was lower among those invited to undergo screening colonoscopy than among those assigned to no screening. Oct 27
  118. Editorial Understanding the Results of a Randomized Trial of Screening Colonoscopy
  119. https://www.nejm.org/doi/full/10.1056/NEJMoa2208375?query=featured_home
  120. Editorial
  121. Assessing the Effect of Vaccination and Prior SARS-CoV-2 Infection E.J. Rubin, L.R. Baden, and S. Morrissey In this audio interview conducted on October 25, the editors discuss the protective effect of vaccination and prior infection against Covid-19. Oct 27
  122. https://www.nejm.org/doi/full/10.1056/NEJMe2214027?query=featured_home
  123. Original Article
  124. Protection against Omicron in California Prisons E.T. Chin and Others Unvaccinated persons without previous Covid-19 had the highest risk of omicron infection; those who had been infected after emergence of the delta variant and had received three mRNA vaccine doses were the most protected. Oct 26
  125. https://www.nejm.org/doi/full/10.1056/NEJMoa2207082?query=featured_home
  126. Review Article
  127. Monkeypox A. Gessain, E. Nakoune, and Y. Yazdanpanah Monkeypox cases reported in the United Kingdom, Portugal, and Italy in May 2022 led the WHO to declare a global health emergency. The authors review the virology, epidemiology, clinical features, and treatment of monkeypox. Oct 26
  128. https://www.nejm.org/doi/full/10.1056/NEJMra2208860?query=featured_home
  129. Medicine and Society
  130. Abortion Restrictions and Mental Health Inequity L. Ogbu-Nwobodo and Others Applying an intersectional lens encompassing structural racism, reproductive injustice, and mental health makes it clear that the Dobbs decision will exacerbate health inequities. Oct 27
  131. https://www.nejm.org/doi/full/10.1056/NEJMms2211124?query=featured_home
  132. Perspective
  133. Fundamentals of Health Law
  134. Medical Malpractice Law — Doctrine and Dynamics D.M. Studdert and M.A. Hall Establishing a malpractice claim in the United States requires proving a defendant breached a duty of care and injury resulted. How does the process work, and why have paid claims dropped by 75% in the past 20 years? Oct 27
  135. https://www.nejm.org/doi/full/10.1056/NEJMp2201675?query=featured_home
  136. Interactive Medical Case
  137. A Shear Decline J.W. Ostrominski and Others This interactive case describes a 59-year-old man who presented to the ED with worsening fatigue and headache. While describing his symptoms, he became unable to produce fluent speech. Test your diagnostic and therapeutic skills. Oct 27
  138. https://www.nejm.org/doi/full/10.1056/NEJMimc2117464?query=featured_home
  139. Perspective
  140. Abortion Access as a Racial Justice Issue K.B. Kozhimannil, A. Hassan, and R.R. Hardeman The Dobbs decision rolls back fundamental rights for many people, and it is a direct assault on efforts to improve racial equity in health care. Indeed, abortion access is fundamentally a racial justice issue. Oct 27
  141. https://www.nejm.org/doi/full/10.1056/NEJMp2209737?query=featured_home
  142. Perspective
  143. Double Take
  144. Migraine — Patient Perspectives C.E. Armand and Others In this Double Take video for patients and families, patients share their experiences of living with migraine and physicians discuss the history and current understanding of this common condition. Oct 27
  145. Original Article Ubrogepant for the Treatment of Migraine
  146. Review Article Migraine
  147. Original Article Atogepant for the Preventive Treatment of Migraine
  148. https://www.nejm.org/doi/full/10.1056/NEJMp2213217?query=featured_home
  149. Covid-19 Vaccine Resource Center
  150. Learn More
  151. Image of the Week
  152. Arm Pain and Swelling after Blunt Trauma
  153. https://www.nejm.org/action/clickThrough?id=125307&url=https%3A%2F%2Fwww.nejm.org%2Fclimate-change%3Futm_source%3Dnejm%26utm_medium%3Dcm%26utm_campaign%3Dcc%26utm_term%3Dhp&loc=%2F&placeholderId=101328&productId=1007
  154. Most Viewed
  155. Correspondence Oct 19, 2022 Myocarditis after BNT162b2 Vaccination in Israeli Adolescents G. Witberg and Others
  156. Review Article Oct 20, 2022 Myocarditis C. Basso
  157. Original Article Oct 19, 2022 Evaluation of mRNA-1273 Vaccine in Children 6 Months to 5 Years of Age E. J. Anderson and Others
  158. https://www.nejm.org/doi/full/10.1056/NEJMoa2209813?query=featured_home
  159. Original Article
  160. Neoadjuvant Cemiplimab for Locally Advanced Skin Cancer N.D. Gross and Others A phase 2, multicenter study showed that four doses of neoadjuvant cemiplimab (anti–PD-1 antibody) led to a pathological complete response in 51% of patients with locally advanced cutaneous squamous-cell carcinoma. Oct 27
  161. https://www.nejm.org/doi/full/10.1056/NEJMoa2209813?query=featured_home
  162. Original Article
  163. Racial and Ethnic-Group Differences in Bystander CPR R.A. Garcia and Others From 2013 through 2019, Black and Hispanic persons who had out-of-hospital cardiac arrest were less likely than White persons to receive bystander CPR at home or in public places. Oct 27
  164. Editorial Social Determinants of Sudden Cardiac Death
  165. https://www.nejm.org/doi/full/10.1056/NEJMoa2200798?query=featured_home
  166. Original Article
  167. DHA Supplementation and IQ after Preterm Birth J.F. Gould and Others Children born very prematurely are deprived of maternal docosahexaenoic acid. This study shows an IQ at 5 years of age that was 3.5 points higher among children who had received neonatal DHA supplementation. Oct 27
  168. https://www.nejm.org/doi/full/10.1056/NEJMoa2206868?query=featured_home
  169. Original Article
  170. Assessing Strategies for Spontaneous-Breathing Trials A.W. Thille and Others Among patients with a high risk of reintubation, spontaneous-breathing trials performed with pressure-support ventilation did not result in significantly more ventilator-free days at day 28 than T-piece trials. Oct 26
  171. Editorial Improved Protocols for Ventilator Liberation
  172. https://www.nejm.org/doi/full/10.1056/NEJMoa2209041?query=featured_home
  173. Original Article
  174. mRNA-1273 in Children 6 Months to 5 Years of Age E.J. Anderson and Others In a randomized, placebo-controlled trial involving children 6 months to 5 years of age, the mRNA-1273 vaccine was shown to be safe, and the elicited antibody responses were similar to those in young adults. Oct 19
  175. https://www.nejm.org/doi/full/10.1056/NEJMoa2209367?query=featured_home
  176. Original Article
  177. Early Mobilization during Ventilation in the ICU The TEAM Study Investigators and the ANZICS Clinical Trials Group In this trial involving patients undergoing mechanical ventilation in the ICU, an increase in early mobilization did not improve the number of days alive and out of the hospital. Oct 26
  178. Editorial Early Mobilization of Critical Care Patients — Still More to Learn
  179. https://www.nejm.org/doi/full/10.1056/NEJMoa2209083?query=featured_home
  180. Correspondence
  181. Hemostasis in Surgery after Factor IX Gene Therapy F. Xue and Others A 26-year-old man who had received successful gene therapy for hemophilia B underwent total knee arthroplasty 16 months later, with a factor IX level of 50 IU per deciliter. There was no excessive bleeding and no need for additional factor IX infusion. Oct 27
  182. https://www.nejm.org/doi/full/10.1056/NEJMc2211173?query=featured_home
  183. https://www.nejm.org/action/clickThrough?id=125344&url=https%3A%2F%2Fstore.nejm.org%2Fsignup%2Fnejm%2Fregister%2Falerts%3Falert%3Dnejm-toc%26promo%3DONFQAA21%26query%3Dcm_hp2%26utm_source%3Dnejm%26utm_medium%3Dcm%26utm_campaign%3Dalerts20&loc=%2F&placeholderId=1302&productId=1035
  184. Case Records of the Massachusetts General Hospital
  185. A Girl with Redness of the Eyes E.M. Cohen and Others An 11-year-old girl with latent tuberculosis infection was evaluated for eye redness of 8 weeks’ duration. Funduscopy had shown optic-disk edema, peripheral retinal hemorrhages, and perivascular exudates. What is the diagnosis? Oct 27
  186. This article includes the answer to our latest Case Challenge.
  187. https://www.nejm.org/doi/full/10.1056/NEJMcpc2201235?query=featured_home
  188. Review Article
  189. Myocarditis C. Basso Myocarditis has increased with Covid-19 and Covid-19 vaccines. Precise diagnosis relies on endomyocardial biopsy, but MRI and myocardial markers may be used. Treatment depends on the cause and degree of functional compromise. Oct 20
  190. https://www.nejm.org/doi/full/10.1056/NEJMra2114478?query=featured_home
  191. Case Records of the Massachusetts General Hospital
  192. A Man with Postoperative Cardiogenic Shock and Diffuse Rash A.S. Desai and Others A 76-year-old man was evaluated for persistent postoperative cardiogenic shock and new diffuse rash after undergoing mitral-valve replacement. The patient received oxacillin. Management decisions were made. Oct 20
  193. https://www.nejm.org/doi/full/10.1056/NEJMcpc2201245?query=featured_home
  194. https://www.nejm.org/doi/full/10.1056/NEJMra2201449?query=featured_home
  195. Review Article
  196. Intracranial Hemorrhage K.N. Sheth Spontaneous brain hemorrhages result from chronic hypertension, anticoagulation, or amyloid angiopathy. Tissue disruption from the hematoma can be followed by brain edema and expansion of the clot that worsen prognosis. Oct 27
  197. https://www.nejm.org/doi/full/10.1056/NEJMra2201449?query=featured_home
  198. Perspective
  199. Double Take
  200. Atrial Fibrillation — What Is It and How Is It Treated? E.M. Antman and Others In this Double Take video for patients and families, physicians discuss the history, diagnosis, and treatment of atrial fibrillation, with a specific focus on catheter ablation therapy. Oct 20
  201. https://www.nejm.org/doi/full/10.1056/NEJMp2212939?query=featured_home
  202. https://www.nejm.org/action/clickThrough?id=125350&url=https%3A%2F%2Fevents.catalyst.nejm.org%2Fevents%2Fthe-health-care-workforce-crisis%3Fpromo%3DOCFQD22H%26query%3Dcm-rr-homepromo%26utm_source%3Dncat%26utm_medium%3Dcm%26utm_campaign%3D2022_eventdec&loc=%2F&placeholderId=1162&productId=1007
  203. https://www.nejm.org/do/10.1056/NEJMdo006730/full/
  204. Quick Take
  205. Neoadjuvant Cemiplimab for Squamous-Cell Carcinoma
  206. https://www.nejm.org/do/10.1056/NEJMdo006728/full/
  207. Quick Take
  208. Colonoscopy Screening and Risks of Colorectal Cancer and Related Death
  209. https://www.nejm.org/do/10.1056/NEJMdo006732/full/
  210. Quick Take
  211. DHA in Preterm Infants and IQ at 5 Years
  212. https://www.nejm.org/do/10.1056/NEJMdo006721/full/
  213. Quick Take
  214. BP Targets in Comatose Cardiac Arrest Survivors
  215. https://www.nejm.org/do/10.1056/NEJMdo006719/full/
  216. Quick Take
  217. Ruxolitinib Cream for Vitiligo
  218. https://www.nejm.org/do/10.1056/NEJMdo006723/full/
  219. Quick Take
  220. Oxygen Targets in Cardiac Arrest
  221. https://www.nejm.org/do/10.1056/NEJMdo006725/full/
  222. Quick Take
  223. Intermittently Scanned Continuous Glucose Monitoring for Diabetes
  224. https://www.nejm.org/do/10.1056/NEJMdo006706/full/
  225. Quick Take
  226. PCI for Ischemic Left Ventricular Dysfunction
  227. More Multimedia
  228. Perspective
  229. Medical Malpractice Law — Doctrine and Dynamics D.M. Studdert and M.A. Hall
  230. Perspective
  231. Abortion Access as a Racial Justice Issue K.B. Kozhimannil, A. Hassan, and R.R. Hardeman
  232. Editorial
  233. Social Determinants of Sudden Cardiac Death W.K. Clair
  234. Editorial
  235. Understanding the Results of a Randomized Trial of Screening Colonoscopy J.A. Dominitz and D.J. Robertson
  236. Perspective
  237. National Coverage Determination for Aducanumab S.S. Dhruva, R. Ramachandran, and J.S. Ross
  238. Perspective
  239. What Covid Has Taught the World about Ethics E.J. Emanuel, R.E.G. Upshur, and M.J. Smith
  240. Neonatal Monkeypox Virus Infection
  241. Protective Effect of Previous SARS-CoV-2 Infection against Omicron BA.4 and BA.5 Subvariants
  242. Total Knee Arthroplasty after Gene Therapy for Hemophilia B
  243. Vitamin D and Incident Fractures
  244. Spina Bifida
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Security
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