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Most recent job postings at cancer
via Nature
schedule_type: Full-time
The National Cancer Institute (NCI) is seeking an outstanding, internationally recognized, and visionary scientist to build and lead a new Center for Cancer Bioengineering (CCBE) in the NCI Center for Cancer Research (CCR). This position is a key component of a major initiative to establish a world-class bioengineering community dedicated to cancer in the Intramural Program at the National... Institutes of Health (NIH). The position is equivalent
The National Cancer Institute (NCI) is seeking an outstanding, internationally recognized, and visionary scientist to build and lead a new Center for Cancer Bioengineering (CCBE) in the NCI Center for Cancer Research (CCR). This position is a key component of a major initiative to establish a world-class bioengineering community dedicated to cancer in the Intramural Program at the National... Institutes of Health (NIH). The position is equivalent to a tenured academic department chair.The successful candidate will provide scientific and administrative leadership to build a new research center that develops and applies engineering principles to address critical problems in the detection, diagnosis, biology, and treatment of cancer. Areas of focus may include, but are not limited to, development of biomaterials, 3D cell and tissue engineering, immunomodulation, synthetic biology, nanoparticles, microfluidics and drug delivery.The inaugural director of the CCBE will define overall scientific strategy and direction of the center through recruitment of junior and senior faculty. The center will be a centerpiece of a growing community of engineers at the NIH, particularly at the NCI, the NIH Clinical Center and the National Institute of Biomedical Imaging and Bioengineering (NIBIB). The center director will have the opportunity to build engineering infrastructure within newly renovated space on our Frederick, MD campus that complements the extensive chemical, structural, imaging, biological and clinical state-of-art technologies that exist within the CCR. The successful applicant will also oversee mentoring and training activities and is responsible for ensuring an inclusive, diverse, collaborative, and healthy work environment. You will be asked to submit a statement with your application that describes specific descriptions of activities including teaching and mentoring, participation on committees or workshops addressing diversity, equity, and inclusion (DEI) issues, and recruitment efforts aimed at DEI.In addition to directing the CCBE, the director will also be appointed as a tenured NIH Senior Investigator and will lead their own individual world-class research program, supported by generous stable resources, including access to a wide range of NCI technology platforms and interdisciplinary collaborations within NCI, as well as at NIH and its Clinical Center.The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists pursue the most important and challenging problems in cancer research. The CCR research portfolio covers the full spectrum of biomedical research, ranging from basic to translational and clinical. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside, where clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research. For an overview of CCR, please visit http://ccr.cancer.gov/.The successful candidate must have a Ph.D., M.D/Ph.D or equivalent, an established record in bioengineering, demonstrated leadership ability, proven effectiveness in mentoring and must meet the criteria for NIH tenure. This position is located at the Frederick, MD campus.Salary will be commensurate with experience. A full civil service package of benefits (including health insurance, life insurance, and retirement) is available. Candidates may be U.S. citizens, U.S. permanent residents, or eligible for a visa that will enable work in the United States. This position is subject to a background investigation.Interested candidates should submit the following materials:
Letter of interest, including a career synopsis (maximum 2 pages)
Vision statement for developing a new Center of Bioengineering with the CCR (maximum 2 pages)
Statement of research interests (maximum 3 pages)
Statement of Diversity, Equity and Inclusion (DEI) involvement (maximum 2 pages)
Current curriculum vitae (CV) and complete bibliography.
For more information, contact CCR’s Faculty Recruitment Coordinator at hollidal@mail.nih.gov.Applications should be submitted electronically to https://service.cancer.gov/ccr-careers and will be accepted until the position is filled. Review of applications will begin February 15, 2023 Show more details...
Letter of interest, including a career synopsis (maximum 2 pages)
Vision statement for developing a new Center of Bioengineering with the CCR (maximum 2 pages)
Statement of research interests (maximum 3 pages)
Statement of Diversity, Equity and Inclusion (DEI) involvement (maximum 2 pages)
Current curriculum vitae (CV) and complete bibliography.
For more information, contact CCR’s Faculty Recruitment Coordinator at hollidal@mail.nih.gov.Applications should be submitted electronically to https://service.cancer.gov/ccr-careers and will be accepted until the position is filled. Review of applications will begin February 15, 2023 Show more details...
via Science Careers
schedule_type: Full-time
The Center for Immuno-Oncology (CIO) Translational Research area at the National Cancer Institute functions as a multidisciplinary and interdisciplinary translational research programmatic effort with the goal of developing novel immunotherapies and immunotherapeutic strategies for cancer. Focus is placed on the development of novel immunotherapeutics, not only as monotherapies, but more... importantly, in combination with other immune-mediating modalities,
The Center for Immuno-Oncology (CIO) Translational Research area at the National Cancer Institute functions as a multidisciplinary and interdisciplinary translational research programmatic effort with the goal of developing novel immunotherapies and immunotherapeutic strategies for cancer. Focus is placed on the development of novel immunotherapeutics, not only as monotherapies, but more... importantly, in combination with other immune-mediating modalities, and other conventional or experimental therapies, as part of an immuno-oncology programmatic effort. Within this effort are several research groups which interact closely with the clinical groups of the CIO, and with collaborators within the NCI intramural and extramural programs, and with investigators in the private sector. As Co-Director of the CIO, Dr. Jeffrey Schlom directs the Translational Research area of investigation.
The program takes advantage of the uniqueness of the NCI intramural program in that it spans high-risk basic discovery research in immunology genomics and tumor biology, through preclinical translational research, to paradigm-shifting clinical trials. Focus is placed on the design and development of novel 'off-the-shelf' recombinant (rec.) immunotherapeutics that can be used in clinical studies at numerous institutions. A major strength of the program is the rapid translation of preclinical studies to hypothesis-generating clinical trials.
We are looking for post-doctoral fellows interested in learning immunology and immunotherapy. This full-time training position is available immediately. The appointment duration is up to 5 years. The job requires an Ph.D., M.D., or equivalent in immunology, molecular/cell biology or experimental pathology. Stipends are commensurate with education and experience.
Please send a cover letter describing your research experience and interests, CV including bibliography, and contact information for three references to:
Jeffrey Schlom, Ph.D., via e-mail: js141c@nih.gov
Please write "Postdoctoral application" in the subject heading. No calls, please. If we are interested, you will be contacted by Dr. Schlom.
Please refer to the Center for Immuno-Oncology's website
https://ccr.cancer.gov/center-for-immuno-oncology
and Dr. Schlom’s profile page https://ccr.cancer.gov/staff-directory/jeffrey-schlom
to learn more about the CIO and its research.
DHHS, NIH and NCI are equal opportunity employers. The NCI and CCR are deeply committed to diversity of thought, equity and inclusion and encourage applications from qualified women, underrepresented minorities and individuals with disabilities Show more details...
The program takes advantage of the uniqueness of the NCI intramural program in that it spans high-risk basic discovery research in immunology genomics and tumor biology, through preclinical translational research, to paradigm-shifting clinical trials. Focus is placed on the design and development of novel 'off-the-shelf' recombinant (rec.) immunotherapeutics that can be used in clinical studies at numerous institutions. A major strength of the program is the rapid translation of preclinical studies to hypothesis-generating clinical trials.
We are looking for post-doctoral fellows interested in learning immunology and immunotherapy. This full-time training position is available immediately. The appointment duration is up to 5 years. The job requires an Ph.D., M.D., or equivalent in immunology, molecular/cell biology or experimental pathology. Stipends are commensurate with education and experience.
Please send a cover letter describing your research experience and interests, CV including bibliography, and contact information for three references to:
Jeffrey Schlom, Ph.D., via e-mail: js141c@nih.gov
Please write "Postdoctoral application" in the subject heading. No calls, please. If we are interested, you will be contacted by Dr. Schlom.
Please refer to the Center for Immuno-Oncology's website
https://ccr.cancer.gov/center-for-immuno-oncology
and Dr. Schlom’s profile page https://ccr.cancer.gov/staff-directory/jeffrey-schlom
to learn more about the CIO and its research.
DHHS, NIH and NCI are equal opportunity employers. The NCI and CCR are deeply committed to diversity of thought, equity and inclusion and encourage applications from qualified women, underrepresented minorities and individuals with disabilities Show more details...
via JAMA Career Center - JAMA Network
schedule_type: Full-time
MAKE AN IMPACT ON THE DEVELOPMENT OF NOVEL ANTICANCER AGENTS COME TRAIN AT THE NATIONAL CANCER INSTITUTE!
The Division of Cancer Treatment and Diagnosis (DCTD), National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (HHS), is seeking energetic and dedicated candidates for the position of Clinical Fellow/Senior Clinical Fellow in the DCTD... Clinical Oncology Advanced Developmental Therapeutics
MAKE AN IMPACT ON THE DEVELOPMENT OF NOVEL ANTICANCER AGENTS COME TRAIN AT THE NATIONAL CANCER INSTITUTE!
The Division of Cancer Treatment and Diagnosis (DCTD), National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (HHS), is seeking energetic and dedicated candidates for the position of Clinical Fellow/Senior Clinical Fellow in the DCTD... Clinical Oncology Advanced Developmental Therapeutics Training Program (ADTTP). Increased number of novel therapeutic agents and the progressively greater complexity of early clinical trials have led to a need for more physicians with special skills in drug development. The major objective of the ADTTP is to provide medical oncologists advanced training in state-of-the-science principles and technologies of developmental therapeutics by utilizing the unique resources available within the National Cancer Institute (NCI).
The successful candidate(s) will participate in clinical research conducted at the NIH Clinical Center in Bethesda, MD, Developmental Therapeutics Clinic (DTC) (https://dtc.cancer.gov/), NCI. The program will provide an excellent opportunity to refine skills in clinical investigation including novel strategies for trial design and methodology, protocol development, execution, monitoring, conformity with ethical standards, and formulation of attainable and pertinent laboratory correlates.
The trainee(s) will spend 40-60 percent of effort in clinical investigation involving inpatients and outpatients at the NIH, including a minimum of 1.5 days in DTC clinic activities. In addition, the trainee(s) will spend up to 40 percent effort in the DCTD Cancer Therapy Evaluation Program (CTEP) (https://ctep.cancer.gov/). The CTEP component of the training will broaden the trainee’s knowledge of new drug development by providing a unique opportunity to learn principles and concepts of agent prioritization, drug development strategies, protocol development and review, IND requirements, adverse event assessment and reporting.
Candidates must meet all of the following requirements:
•M.D. or an equivalent degree with a license to practice medicine in the United States
•Completion of subspecialty training in Medical Oncology at a US-accredited institution
•Board certification or eligibility in Medical Oncology
A full federal package of benefits (including retirement, leave, health, life, and a 401K equivalent savings plan, etc.) is available. This is a time-limited federal appointment not-to-exceed 2-3 years (there is no assurance of a tenure-track or permanent position with NIH upon completion of the program). Salary is commensurate with experience.
To apply for this position, please submit your Curriculum Vitae; three letters of recommendation (preferably one from the Medical Oncology training program director or supervisor of last professional position); Permanent Residency documentation, if applicable; and personal statement of research goals to: Monika Sarna, DCTD, NCI Administrative Officer (AO) at: msarna@mail.nih.gov. For more information, please contact Alice Chen, M.D. at: alice.chen@nih.gov.
HHS, NIH AND NCI ARE EQUAL OPPORTUNITY EMPLOYERS Show more details...
The Division of Cancer Treatment and Diagnosis (DCTD), National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (HHS), is seeking energetic and dedicated candidates for the position of Clinical Fellow/Senior Clinical Fellow in the DCTD... Clinical Oncology Advanced Developmental Therapeutics Training Program (ADTTP). Increased number of novel therapeutic agents and the progressively greater complexity of early clinical trials have led to a need for more physicians with special skills in drug development. The major objective of the ADTTP is to provide medical oncologists advanced training in state-of-the-science principles and technologies of developmental therapeutics by utilizing the unique resources available within the National Cancer Institute (NCI).
The successful candidate(s) will participate in clinical research conducted at the NIH Clinical Center in Bethesda, MD, Developmental Therapeutics Clinic (DTC) (https://dtc.cancer.gov/), NCI. The program will provide an excellent opportunity to refine skills in clinical investigation including novel strategies for trial design and methodology, protocol development, execution, monitoring, conformity with ethical standards, and formulation of attainable and pertinent laboratory correlates.
The trainee(s) will spend 40-60 percent of effort in clinical investigation involving inpatients and outpatients at the NIH, including a minimum of 1.5 days in DTC clinic activities. In addition, the trainee(s) will spend up to 40 percent effort in the DCTD Cancer Therapy Evaluation Program (CTEP) (https://ctep.cancer.gov/). The CTEP component of the training will broaden the trainee’s knowledge of new drug development by providing a unique opportunity to learn principles and concepts of agent prioritization, drug development strategies, protocol development and review, IND requirements, adverse event assessment and reporting.
Candidates must meet all of the following requirements:
•M.D. or an equivalent degree with a license to practice medicine in the United States
•Completion of subspecialty training in Medical Oncology at a US-accredited institution
•Board certification or eligibility in Medical Oncology
A full federal package of benefits (including retirement, leave, health, life, and a 401K equivalent savings plan, etc.) is available. This is a time-limited federal appointment not-to-exceed 2-3 years (there is no assurance of a tenure-track or permanent position with NIH upon completion of the program). Salary is commensurate with experience.
To apply for this position, please submit your Curriculum Vitae; three letters of recommendation (preferably one from the Medical Oncology training program director or supervisor of last professional position); Permanent Residency documentation, if applicable; and personal statement of research goals to: Monika Sarna, DCTD, NCI Administrative Officer (AO) at: msarna@mail.nih.gov. For more information, please contact Alice Chen, M.D. at: alice.chen@nih.gov.
HHS, NIH AND NCI ARE EQUAL OPPORTUNITY EMPLOYERS Show more details...
via Science Careers
posted_at: 12 days agoschedule_type: Full-time
Antibody Engineering, T cell engineering, Cancer Immunotherapy – Postdoctoral Fellowship
National Cancer Institute, Bethesda, MD...
Position Description:
Dr. Mitchell Ho’s laboratory at the National Cancer Institute (NCI) Center for Cancer Research (CCR) has characterized cell surface proteins such as glypicans including GPC1, GPC2 and GPC3, B7-H3 (CD276), and mesothelin as immunotherapeutic targets in solid tumors such as liver cancer, pancreatic
Antibody Engineering, T cell engineering, Cancer Immunotherapy – Postdoctoral Fellowship
National Cancer Institute, Bethesda, MD...
Position Description:
Dr. Mitchell Ho’s laboratory at the National Cancer Institute (NCI) Center for Cancer Research (CCR) has characterized cell surface proteins such as glypicans including GPC1, GPC2 and GPC3, B7-H3 (CD276), and mesothelin as immunotherapeutic targets in solid tumors such as liver cancer, pancreatic cancer and childhood cancers. We have used molecular and cellular biology, computational structure modeling, RNA sequencing (RNA-seq), and mouse tumor models to develop single-domain antibody (nanobody) technology, isolate antibodies targeting tumor-specific epitopes, and engineer CAR or TCR constructs for designing novel T cell-based immunotherapies. There are two postdoctoral positions available in the Ho lab, one for antibody discovery (phage display) and protein engineering in the antibody engineering core and the other for T cell engineering and preclinical testing using mouse tumor models in the antibody therapy section. Some of our research have the potential for direct clinical application.
Detailed information about our research program and publications can be accessed: https://ccr.cancer.gov/mitchell-ho
Qualifications:
Candidates are expected to have completed, or be completing, a Ph.D. or M.D./Ph.D. with a strong publication record. Highly motivated candidates who are interested in innovative, high-impact basic and translational research are encouraged to apply. A background in biochemistry, molecular and cell biology, and/or biomedical engineering is required. Experience with mouse tumor models, RNA-seq, protein structure and/or computational skills is a plus.
To Apply:
Applications should be sent by e-mail to Dr. Mitchell Ho (homi@mail.nih.gov). Each application should consist of a cover letter describing your research experience and interests, curriculum vitae, bibliography, and contact information of three references.
This position is subject to a background investigation. The NIH is dedicated to building a diverse community in its training and employment programs Show more details...
National Cancer Institute, Bethesda, MD...
Position Description:
Dr. Mitchell Ho’s laboratory at the National Cancer Institute (NCI) Center for Cancer Research (CCR) has characterized cell surface proteins such as glypicans including GPC1, GPC2 and GPC3, B7-H3 (CD276), and mesothelin as immunotherapeutic targets in solid tumors such as liver cancer, pancreatic cancer and childhood cancers. We have used molecular and cellular biology, computational structure modeling, RNA sequencing (RNA-seq), and mouse tumor models to develop single-domain antibody (nanobody) technology, isolate antibodies targeting tumor-specific epitopes, and engineer CAR or TCR constructs for designing novel T cell-based immunotherapies. There are two postdoctoral positions available in the Ho lab, one for antibody discovery (phage display) and protein engineering in the antibody engineering core and the other for T cell engineering and preclinical testing using mouse tumor models in the antibody therapy section. Some of our research have the potential for direct clinical application.
Detailed information about our research program and publications can be accessed: https://ccr.cancer.gov/mitchell-ho
Qualifications:
Candidates are expected to have completed, or be completing, a Ph.D. or M.D./Ph.D. with a strong publication record. Highly motivated candidates who are interested in innovative, high-impact basic and translational research are encouraged to apply. A background in biochemistry, molecular and cell biology, and/or biomedical engineering is required. Experience with mouse tumor models, RNA-seq, protein structure and/or computational skills is a plus.
To Apply:
Applications should be sent by e-mail to Dr. Mitchell Ho (homi@mail.nih.gov). Each application should consist of a cover letter describing your research experience and interests, curriculum vitae, bibliography, and contact information of three references.
This position is subject to a background investigation. The NIH is dedicated to building a diverse community in its training and employment programs Show more details...
via Indeed
posted_at: 7 hours agoschedule_type: Full-time
Bioinformatics Analyst IV
Job ID: req3398...
Employee Type: exempt full-time
Division: Bioinformatics and Computational Science
Facility: NIH
Location: NIH Campus 9000 Rockville Pike, Bethesda, MD 20892 USA
The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc. The lab addresses some of the most urgent and intractable
Bioinformatics Analyst IV
Job ID: req3398...
Employee Type: exempt full-time
Division: Bioinformatics and Computational Science
Facility: NIH
Location: NIH Campus 9000 Rockville Pike, Bethesda, MD 20892 USA
The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc. The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.
Accountability, Compassion, Collaboration, Dedication, Integrity and Versatility; it's the FNL way.
PROGRAM DESCRIPTION
The Frederick National Laboratory is dedicated to improving human health through the discovery and innovation in the biomedical sciences, focusing on cancer, AIDS and emerging infectious diseases.
The Bioinformatics and Computational Science (BACS) Directorate works collaboratively and helps to fulfill the mission of Frederick National Laboratory in the areas of bioinformatics and computational science by developing and applying world-leading computing technologies to basic and applied biomedical research challenges, data science, supporting critical operations, developing and delivering national data resources, and utilizing leading-edge software.
The Advanced Biomedical and Computational Science (ABCS) group is a part of BACS and serves as a hub of translational scientists with expertise in machine learning applied to the interpretation of 2D and 3D biomedical images, clinical and genomics integration, computational chemistry, protein modeling, bioinformatic analysis of omics data, and other applications of computational and data science. ABCS develops state-of-the-art technologies in large-scale data modeling, analysis, and integration and supports the scientific research at the Frederick National Lab by helping translate scientific questions to technical solutions for cancer and biomedical research.
The Genetics Branch (GB, Center for Cancer Research, NCI, (https://ccr.cancer.gov/Genetics-Branch) undertakes basic research as well as clinical and translational research activities. Under the purview of the basic research umbrella, the branch conducts research on the elucidation of the necessary and sufficient factors that govern genetic instability, the description of common/disparate themes among different types of instability, and the cataloging of distinct patterns of gene expression in tumors compared to normal tissues. Under the mantle of clinical research, the branch undertakes patient cancer risk screening, education, counseling, genetic testing, and the development of appropriate surveillance and prevention options that take into account the category of risk that an individual patient, family, or population represents. The translational research that supports this clinical enterprise consists of four components: (1) molecular diagnostics; (2) genotype/phenotype correlations; (3) the development of biomarkers that can be used for risk assessment and as intermediate endpoints for chemoprevention trials; and (4) targeted therapy and assays for active agents based on the underlying genetics and mechanism(s) of genetic instability that distinguish a tumor from the normal cells from which it arose. Under the leadership of Dr. Paul Meltzer (Chief) and Dr. Javed Khan (Deputy Chief), the branch comprises of several research groups led by Principal Investigators focusing on complementary areas of interest. In FY 2021, the Genetics Branch (GB) formed an OMICS facility which will provide access to state-of-the-art OMICS technologies and computational biology resources and support to GB Investigators. The OMICS facility also plans on developing and implementing tools for data integration and databases to allow easy access to all the data for all staff in the branch including trainees.
KEY ROLES/RESPONSIBILITIES
• Communicate in a clear and effective manner
• Prepare output and reports to enable interpretation of results and facilitate next steps
• Prepare and deliver scientific presentations and posters
• Assist in preparing project updates for the branch
• Independently prepare project updates for PIs
• Develop analysis strategies and documents in a clear and consistent manner
• Provide technical expertise in the following areas of bioinformatics
• Interact with colleagues across NCI and FNL to maintain technical currency in bioinformatics, analysis workflows, new technologies, and scientific advances
• Optimize and streamline bioinformatics workflow scripts as needed
• Develop and document protocols consistent with NCI standards and publication
• Ability to analyze scripts and perform basic troubleshooting of bioinformatics workflows
• Adept at running selected programs for NGS analysis of genomic tumor/normal samples along with epigenetic interpretation
• Independently perform hands-on analysis of complex NGS datasets and interpret output within context of the experimental design of the project
• Provide bioinformatics leadership and mentoring
• Detailed understanding of principal relationships in data, algorithms, and program outputs for the bioinformatics pipelines and analyses relevant to lab projects
• Develop and implement new algorithms to improve the analysis/understanding as needed to support branch projects
• Project management and supervision of team members
• Provide integrated project management across the project portfolio
• Participate in generating performance & resource utilization metrics to both ABCS and CCR on a monthly and annual basis
• Provide technical supervision to junior team members through daily & weekly discussions on ongoing projects
• Provide expert judgement on technical analytical issues as well as pipelining efforts
• Participate and contribute to bioinformatics strategy discussions within the Genetics Branch as well as within ABCS
• Participate in hiring efforts, which includes but not limited to preparation of hiring documents, interviewing and providing onboarding support for new hires
• Other duties as required
BASIC QUALIFICATIONS
To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:
• Possession of a Master’s degree in Computer Science, Math or Biomedical Science related field from an accredited college or university according to the Council for Higher Education Accreditation (CHEA)
• Foreign degrees must be evaluated for U.S. equivalency
• In addition to the education requirement, a minimum of ten (10) years of progressively responsible experience
• Knowledge of Unix command line and scripting languages like Python and R
• Hands-on experience with the analysis and interpretation of Next-generation sequencing datasets (Bulk RNASeq, single-cell RNASeq, ATAC-Seq, Cut&Run, Whole-exome and Whole-genome sequencing etc.)
• Ability to obtain and maintain a security clearance
PREFERRED QUALIFICATIONS
Candidates with these desired skills will be given preferential consideration:
• A Masters’ or PhD degree in any quantitative science is preferred
• Commitment to solving biological problems and communicating these solutions
• Ability to multi-task across projects
• Experience in creating NGS workflows on HPC or Cloud environments
• Management of large genomic data sets including integration with data available from public sources
• Prior customer-facing role
• Record of scientific achievements including journal publications and conference presentations
EXPECTED COMPETENCIES
• Proficiency in at least two of the following programming languages: Python, R, Perl, Java and C/C++
• Experience in at least two of the following areas: Exome sequencing, metagenomics, ChIPSeq, RNASeq, DHS-Seq, microarray analysis, DNA methylation analysis
• Familiarity with public databases: NCBI, Ensembl, TCGA, cBioPortal, Broad FireHose
• Knowledge of working in a cluster environment
Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)
#readytowork Show more details...
Job ID: req3398...
Employee Type: exempt full-time
Division: Bioinformatics and Computational Science
Facility: NIH
Location: NIH Campus 9000 Rockville Pike, Bethesda, MD 20892 USA
The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc. The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.
Accountability, Compassion, Collaboration, Dedication, Integrity and Versatility; it's the FNL way.
PROGRAM DESCRIPTION
The Frederick National Laboratory is dedicated to improving human health through the discovery and innovation in the biomedical sciences, focusing on cancer, AIDS and emerging infectious diseases.
The Bioinformatics and Computational Science (BACS) Directorate works collaboratively and helps to fulfill the mission of Frederick National Laboratory in the areas of bioinformatics and computational science by developing and applying world-leading computing technologies to basic and applied biomedical research challenges, data science, supporting critical operations, developing and delivering national data resources, and utilizing leading-edge software.
The Advanced Biomedical and Computational Science (ABCS) group is a part of BACS and serves as a hub of translational scientists with expertise in machine learning applied to the interpretation of 2D and 3D biomedical images, clinical and genomics integration, computational chemistry, protein modeling, bioinformatic analysis of omics data, and other applications of computational and data science. ABCS develops state-of-the-art technologies in large-scale data modeling, analysis, and integration and supports the scientific research at the Frederick National Lab by helping translate scientific questions to technical solutions for cancer and biomedical research.
The Genetics Branch (GB, Center for Cancer Research, NCI, (https://ccr.cancer.gov/Genetics-Branch) undertakes basic research as well as clinical and translational research activities. Under the purview of the basic research umbrella, the branch conducts research on the elucidation of the necessary and sufficient factors that govern genetic instability, the description of common/disparate themes among different types of instability, and the cataloging of distinct patterns of gene expression in tumors compared to normal tissues. Under the mantle of clinical research, the branch undertakes patient cancer risk screening, education, counseling, genetic testing, and the development of appropriate surveillance and prevention options that take into account the category of risk that an individual patient, family, or population represents. The translational research that supports this clinical enterprise consists of four components: (1) molecular diagnostics; (2) genotype/phenotype correlations; (3) the development of biomarkers that can be used for risk assessment and as intermediate endpoints for chemoprevention trials; and (4) targeted therapy and assays for active agents based on the underlying genetics and mechanism(s) of genetic instability that distinguish a tumor from the normal cells from which it arose. Under the leadership of Dr. Paul Meltzer (Chief) and Dr. Javed Khan (Deputy Chief), the branch comprises of several research groups led by Principal Investigators focusing on complementary areas of interest. In FY 2021, the Genetics Branch (GB) formed an OMICS facility which will provide access to state-of-the-art OMICS technologies and computational biology resources and support to GB Investigators. The OMICS facility also plans on developing and implementing tools for data integration and databases to allow easy access to all the data for all staff in the branch including trainees.
KEY ROLES/RESPONSIBILITIES
• Communicate in a clear and effective manner
• Prepare output and reports to enable interpretation of results and facilitate next steps
• Prepare and deliver scientific presentations and posters
• Assist in preparing project updates for the branch
• Independently prepare project updates for PIs
• Develop analysis strategies and documents in a clear and consistent manner
• Provide technical expertise in the following areas of bioinformatics
• Interact with colleagues across NCI and FNL to maintain technical currency in bioinformatics, analysis workflows, new technologies, and scientific advances
• Optimize and streamline bioinformatics workflow scripts as needed
• Develop and document protocols consistent with NCI standards and publication
• Ability to analyze scripts and perform basic troubleshooting of bioinformatics workflows
• Adept at running selected programs for NGS analysis of genomic tumor/normal samples along with epigenetic interpretation
• Independently perform hands-on analysis of complex NGS datasets and interpret output within context of the experimental design of the project
• Provide bioinformatics leadership and mentoring
• Detailed understanding of principal relationships in data, algorithms, and program outputs for the bioinformatics pipelines and analyses relevant to lab projects
• Develop and implement new algorithms to improve the analysis/understanding as needed to support branch projects
• Project management and supervision of team members
• Provide integrated project management across the project portfolio
• Participate in generating performance & resource utilization metrics to both ABCS and CCR on a monthly and annual basis
• Provide technical supervision to junior team members through daily & weekly discussions on ongoing projects
• Provide expert judgement on technical analytical issues as well as pipelining efforts
• Participate and contribute to bioinformatics strategy discussions within the Genetics Branch as well as within ABCS
• Participate in hiring efforts, which includes but not limited to preparation of hiring documents, interviewing and providing onboarding support for new hires
• Other duties as required
BASIC QUALIFICATIONS
To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:
• Possession of a Master’s degree in Computer Science, Math or Biomedical Science related field from an accredited college or university according to the Council for Higher Education Accreditation (CHEA)
• Foreign degrees must be evaluated for U.S. equivalency
• In addition to the education requirement, a minimum of ten (10) years of progressively responsible experience
• Knowledge of Unix command line and scripting languages like Python and R
• Hands-on experience with the analysis and interpretation of Next-generation sequencing datasets (Bulk RNASeq, single-cell RNASeq, ATAC-Seq, Cut&Run, Whole-exome and Whole-genome sequencing etc.)
• Ability to obtain and maintain a security clearance
PREFERRED QUALIFICATIONS
Candidates with these desired skills will be given preferential consideration:
• A Masters’ or PhD degree in any quantitative science is preferred
• Commitment to solving biological problems and communicating these solutions
• Ability to multi-task across projects
• Experience in creating NGS workflows on HPC or Cloud environments
• Management of large genomic data sets including integration with data available from public sources
• Prior customer-facing role
• Record of scientific achievements including journal publications and conference presentations
EXPECTED COMPETENCIES
• Proficiency in at least two of the following programming languages: Python, R, Perl, Java and C/C++
• Experience in at least two of the following areas: Exome sequencing, metagenomics, ChIPSeq, RNASeq, DHS-Seq, microarray analysis, DNA methylation analysis
• Familiarity with public databases: NCBI, Ensembl, TCGA, cBioPortal, Broad FireHose
• Knowledge of working in a cluster environment
Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)
#readytowork Show more details...
via Tarta.ai
posted_at: 2 days agoschedule_type: Full-time
The Molecular Targets Program (MTP) of the National Cancer Institute's Center for Cancer Research
(NCI's CCR) has postdoctoral positions available in its Protein Chemistry and Molecular Biology Section
(PCMBS). The PCMBS uses its expertise in protein chemistry, biophysics, enzymology, molecular...
biology and screening to adapt CCR basic science laboratory findings into high throughput cell-free
screens for the interrogation of pure compound and pre-fractionated
The Molecular Targets Program (MTP) of the National Cancer Institute's Center for Cancer Research
(NCI's CCR) has postdoctoral positions available in its Protein Chemistry and Molecular Biology Section
(PCMBS). The PCMBS uses its expertise in protein chemistry, biophysics, enzymology, molecular...
biology and screening to adapt CCR basic science laboratory findings into high throughput cell-free
screens for the interrogation of pure compound and pre-fractionated natural product libraries. In addition,
we use these same skills to discover and characterize novel bioactive proteins from natural product extracts
that increase our knowledge of protein structure and function, address diseases and molecular targets of
interest, and potentially lead to clinical development.
1. The first position is for a scientist with experience in biochemistry and enzymology. The selected
candidate will be expected to conduct investigations into adapting laboratory cancer biology
discoveries on molecular targets of interest for cancer into bioassays and high-throughput screens
for the discovery of novel natural products. The candidate will also be involved in mechanism of
action studies on natural products that display inhibitory activity against targets of interest.
2. The second position is for a researcher with experience in molecular biology and protein chemistry.
Applicants should have experience in the isolation, physical and functional characterization of
proteins and in the genetic engineering of proteins for expression in E. coli systems. The successful
candidate will engage in efforts to isolate or engineer new bioactive proteins and peptides with
activity against cancer, HIV, and SARS-CoV-2.
The positions are located at the NCI at Frederick Maryland campus. Candidates must have a Ph.D. in
biochemistry, cell/molecular biology, biophysics, pharmacognosy or a related discipline from an
accredited research institution within the last three years. The fellowship duration is for a maximum of 5
years based on performance and yearly evaluations. The fellowship is not restricted to U.S. citizens. The
fellowship stipend starts at $54,100 per annum and is determined based on qualifications and years of
relevant experience. Applicants should submit a cover letter, CV with bibliography, and three letters of
reference to MTP_PostDoc@nih.gov or directly to Dr. Barry R. O‚'Keefe at okeefeba@mail.nih.gov .
More information about the Molecular Targets Program is available here:
https://ccr.cancer.gov/molecular-targets-program.
This position is subject to a background investigation. The NIH is dedicated to building a diverse
community in its training and employment programs; underrepresented minority candidates are
encouraged to apply Show more details...
(NCI's CCR) has postdoctoral positions available in its Protein Chemistry and Molecular Biology Section
(PCMBS). The PCMBS uses its expertise in protein chemistry, biophysics, enzymology, molecular...
biology and screening to adapt CCR basic science laboratory findings into high throughput cell-free
screens for the interrogation of pure compound and pre-fractionated natural product libraries. In addition,
we use these same skills to discover and characterize novel bioactive proteins from natural product extracts
that increase our knowledge of protein structure and function, address diseases and molecular targets of
interest, and potentially lead to clinical development.
1. The first position is for a scientist with experience in biochemistry and enzymology. The selected
candidate will be expected to conduct investigations into adapting laboratory cancer biology
discoveries on molecular targets of interest for cancer into bioassays and high-throughput screens
for the discovery of novel natural products. The candidate will also be involved in mechanism of
action studies on natural products that display inhibitory activity against targets of interest.
2. The second position is for a researcher with experience in molecular biology and protein chemistry.
Applicants should have experience in the isolation, physical and functional characterization of
proteins and in the genetic engineering of proteins for expression in E. coli systems. The successful
candidate will engage in efforts to isolate or engineer new bioactive proteins and peptides with
activity against cancer, HIV, and SARS-CoV-2.
The positions are located at the NCI at Frederick Maryland campus. Candidates must have a Ph.D. in
biochemistry, cell/molecular biology, biophysics, pharmacognosy or a related discipline from an
accredited research institution within the last three years. The fellowship duration is for a maximum of 5
years based on performance and yearly evaluations. The fellowship is not restricted to U.S. citizens. The
fellowship stipend starts at $54,100 per annum and is determined based on qualifications and years of
relevant experience. Applicants should submit a cover letter, CV with bibliography, and three letters of
reference to MTP_PostDoc@nih.gov or directly to Dr. Barry R. O‚'Keefe at okeefeba@mail.nih.gov .
More information about the Molecular Targets Program is available here:
https://ccr.cancer.gov/molecular-targets-program.
This position is subject to a background investigation. The NIH is dedicated to building a diverse
community in its training and employment programs; underrepresented minority candidates are
encouraged to apply Show more details...
via Glassdoor
posted_at: 19 days agoschedule_type: Full-timesalary: 60K–90K a year
A postdoctoral fellow position is available in the laboratory of Dr. Chongyi Chen at the National Cancer Institute (NCI), National Institutes of Health (NIH). The potential projects are to investigate the dynamics and regulation of DNA topology upon mitotic chromosome condensation, and to investigate the role of DNA topology in gene expression regulation in human cells. The Chen lab study... chromatin structure, DNA topology, and gene expression regulation
A postdoctoral fellow position is available in the laboratory of Dr. Chongyi Chen at the National Cancer Institute (NCI), National Institutes of Health (NIH). The potential projects are to investigate the dynamics and regulation of DNA topology upon mitotic chromosome condensation, and to investigate the role of DNA topology in gene expression regulation in human cells. The Chen lab study... chromatin structure, DNA topology, and gene expression regulation in human cells, by various genomic technologies and single-cell sequencing assays newly invented in the lab. For more information about the lab and the PI, please visit: https://ccr.cancer.gov/staff-directory/chongyi-chen
The laboratory is located in the NIH main campus, together with >1000 labs, and >100 National Academy of Sciences/Medicine members. NIH postdocs have access to first-class research facilities, enjoy outstanding salary and benefits often better than their counterparts in universities. We are stably and sufficiently funded intramurally without the pressure of securing grants from time to time, thus have the privilege to focus on producing high-quality science.
We are looking for candidates with strong backgrounds in molecular cell biology, genomics, bioinformatics, or related fields who are passionate and self-motivated in research. Candidates with prior experience in chromatin biology or omics data analysis are especially encouraged to apply.
Interested applicants should send a CV including a publication list and the contact information of references to Dr. Chongyi Chen.
Job Type: Full-time
Pay: $60,000.00 - $90,000.00 per year
Benefits:
• 401(k)
• Health insurance
Schedule:
• Monday to Friday
Education:
• Doctorate (Preferred)
Work Location: One location Show more details...
The laboratory is located in the NIH main campus, together with >1000 labs, and >100 National Academy of Sciences/Medicine members. NIH postdocs have access to first-class research facilities, enjoy outstanding salary and benefits often better than their counterparts in universities. We are stably and sufficiently funded intramurally without the pressure of securing grants from time to time, thus have the privilege to focus on producing high-quality science.
We are looking for candidates with strong backgrounds in molecular cell biology, genomics, bioinformatics, or related fields who are passionate and self-motivated in research. Candidates with prior experience in chromatin biology or omics data analysis are especially encouraged to apply.
Interested applicants should send a CV including a publication list and the contact information of references to Dr. Chongyi Chen.
Job Type: Full-time
Pay: $60,000.00 - $90,000.00 per year
Benefits:
• 401(k)
• Health insurance
Schedule:
• Monday to Friday
Education:
• Doctorate (Preferred)
Work Location: One location Show more details...
via National Association Of Asian American Professionals - NAAAP
posted_at: 19 days agoschedule_type: Full-time
Department of Health and Human Services
National Institutes of Health...
National Cancer Institute
Center for Cancer Research
Senior Biomedical Research Scientist/Biostatistician
The National Cancer Institute’s (NCI) Center for Cancer Research (CCR) seeks a senior Biostatistician to head the Biostatistics and Data Management Section (BDMS) and provide statistical leadership for major activities of the CCR. The BDMS is involved in the design,
Department of Health and Human Services
National Institutes of Health...
National Cancer Institute
Center for Cancer Research
Senior Biomedical Research Scientist/Biostatistician
The National Cancer Institute’s (NCI) Center for Cancer Research (CCR) seeks a senior Biostatistician to head the Biostatistics and Data Management Section (BDMS) and provide statistical leadership for major activities of the CCR. The BDMS is involved in the design, review, conduct, monitoring, and statistical analyses of intramural, and occasionally national or multi-center clinical trials of experimental treatments for cancer, and intramural clinical trials for the treatment of AIDS and AIDS-related malignancies. Investigators throughout the CCR contact the BDMS whenever statistical input is needed for a clinical trial or other projects. The BDMS consults and collaborates with most of the CCR clinical branches and laboratories on clinical projects as well as with many of CCR's basic research laboratories on preclinical research projects. In addition, to clinical trial biostatistics, the section provides a broad range of data analysis and consultation services, including study design, methodological consulting, and analytic services, to laboratories performing basic scientific research into the origin and growth mechanisms of cancer and the biology of AIDS.
The selected individual for this position will serve as the most senior advisor on matters pertaining to experimental design, data analysis, and other biostatistical issues within the CCR. S/he will be responsible for all analytic aspects of a major portion of the clinical trials conducted, and the development of innovative designs for, clinical trials conducted by the CCR of NCI. This position is pivotal in providing authoritative statistical advice and consultation to branch chiefs, section heads, and other senior staff of the CCR. The selected individual will also act as senior advisor on biostatistics as a member of the Scientific Review Committee that evaluates all clinical trials within the CCR, collaborate with researchers on medical, scientific, and statistical publications, and use advanced statistical methods to answer important questions arising from laboratory, clinical, and pathologic investigations. In addition, the selected individual may serve as an advisor on biostatistics to senior scientists outside of NCI. The position will also supervise two highly experienced statisticians.
The CCR is an intramural research component of the NCI located in Bethesda, Maryland. CCR’s enabling infrastructure facilitates clinical studies at the NIH Clinical Center, the nation's largest hospital devoted entirely to clinical research; provides extensive opportunities for collaboration; and allows scientists and clinicians to undertake high-impact laboratory- and clinic-based investigations. Our research teams offer well over 300 clinical research trials and annually open over 50 new trials and enrolls 1,300 new patients. Clinical investigators are supported by a wide array of supportive clinical resources including data management, research nursing, patient care coordination, education, protocol development support, patient referral and outreach, and technology transfer collaborations with industry. The CCR is highly committed to and is taking actionable steps to create a fully equitable work environment, build a diverse cancer research workforce, expand health disparities research, and improve patient representation in clinical trials. Our scientists enjoy complete intellectual freedom and are expected to creatively and innovatively explore the most important questions in the field of cancer research and treatment. We support projects over a long-time horizon allowing our investigators to pursue some of the most difficult, high-risk problems in the field. For an overview of CCR, please visit http://ccr.cancer.gov/.
Eligibility
• Candidates must possess a doctoral degree in biostatistics or related field.
• Expertise using R or SAS for statistical analyses is required and recent experience with both is preferred. Several years of experience designing clinical trials, with multiple years’ experience designing cancer clinical trials desirable.
Conditions of Employment
• Candidates must be US citizens.
• This position is subject to a background investigation.
Salary and Benefits
Salary is commensurate with education and experience. A full federal benefits package is available, including retirement, health insurance, life insurance, annual and sick leave, and the Thrift Savings Plan (401K equivalent).
How to Apply
Interested applicants should submit:
• A letter of interest that includes a career synopsis;
• A current curriculum vitae and complete bibliography;
• A diversity statement describing your track record of and commitment to promoting diversity, equity, and inclusion in biomedical research and/or medicine, including, but not limited to, the understanding of and impacting issues of equity, inclusion, and diversity, successful recruitment and/or mentorship of individuals from historically underrepresented groups, demonstrated sustained efforts to promote diversity, equity and inclusion, and plans for addressing diversity and inclusion in the future. (500-word limit)
Applications must be submitted to: https://service.cancer.gov/ccr-careers. E-mailed or paper applications will not be accepted. Initial review of applications is anticipated to begin on or about March 13, 2023, but applications will be accepted until the position is filled. Applications will be treated as confidential. For more information, contact Patrick Miller, Faculty Recruitment Coordinator at millerp@mail.nih.gov.
NIH provides reasonable accommodations to applicants with disabilities. If you require reasonable accommodation during any part of the application and hiring process, please notify us. The decision on granting reasonable accommodation will be made on a case-by-case basis.
The NCI and the CCR are deeply committed to diversity of thought, equity, and inclusion and encourage applications from qualified women, under-represented minorities, and individuals with disabilities.
The DHHS, NIH and NCI are Equal Opportunity Employers Show more details...
National Institutes of Health...
National Cancer Institute
Center for Cancer Research
Senior Biomedical Research Scientist/Biostatistician
The National Cancer Institute’s (NCI) Center for Cancer Research (CCR) seeks a senior Biostatistician to head the Biostatistics and Data Management Section (BDMS) and provide statistical leadership for major activities of the CCR. The BDMS is involved in the design, review, conduct, monitoring, and statistical analyses of intramural, and occasionally national or multi-center clinical trials of experimental treatments for cancer, and intramural clinical trials for the treatment of AIDS and AIDS-related malignancies. Investigators throughout the CCR contact the BDMS whenever statistical input is needed for a clinical trial or other projects. The BDMS consults and collaborates with most of the CCR clinical branches and laboratories on clinical projects as well as with many of CCR's basic research laboratories on preclinical research projects. In addition, to clinical trial biostatistics, the section provides a broad range of data analysis and consultation services, including study design, methodological consulting, and analytic services, to laboratories performing basic scientific research into the origin and growth mechanisms of cancer and the biology of AIDS.
The selected individual for this position will serve as the most senior advisor on matters pertaining to experimental design, data analysis, and other biostatistical issues within the CCR. S/he will be responsible for all analytic aspects of a major portion of the clinical trials conducted, and the development of innovative designs for, clinical trials conducted by the CCR of NCI. This position is pivotal in providing authoritative statistical advice and consultation to branch chiefs, section heads, and other senior staff of the CCR. The selected individual will also act as senior advisor on biostatistics as a member of the Scientific Review Committee that evaluates all clinical trials within the CCR, collaborate with researchers on medical, scientific, and statistical publications, and use advanced statistical methods to answer important questions arising from laboratory, clinical, and pathologic investigations. In addition, the selected individual may serve as an advisor on biostatistics to senior scientists outside of NCI. The position will also supervise two highly experienced statisticians.
The CCR is an intramural research component of the NCI located in Bethesda, Maryland. CCR’s enabling infrastructure facilitates clinical studies at the NIH Clinical Center, the nation's largest hospital devoted entirely to clinical research; provides extensive opportunities for collaboration; and allows scientists and clinicians to undertake high-impact laboratory- and clinic-based investigations. Our research teams offer well over 300 clinical research trials and annually open over 50 new trials and enrolls 1,300 new patients. Clinical investigators are supported by a wide array of supportive clinical resources including data management, research nursing, patient care coordination, education, protocol development support, patient referral and outreach, and technology transfer collaborations with industry. The CCR is highly committed to and is taking actionable steps to create a fully equitable work environment, build a diverse cancer research workforce, expand health disparities research, and improve patient representation in clinical trials. Our scientists enjoy complete intellectual freedom and are expected to creatively and innovatively explore the most important questions in the field of cancer research and treatment. We support projects over a long-time horizon allowing our investigators to pursue some of the most difficult, high-risk problems in the field. For an overview of CCR, please visit http://ccr.cancer.gov/.
Eligibility
• Candidates must possess a doctoral degree in biostatistics or related field.
• Expertise using R or SAS for statistical analyses is required and recent experience with both is preferred. Several years of experience designing clinical trials, with multiple years’ experience designing cancer clinical trials desirable.
Conditions of Employment
• Candidates must be US citizens.
• This position is subject to a background investigation.
Salary and Benefits
Salary is commensurate with education and experience. A full federal benefits package is available, including retirement, health insurance, life insurance, annual and sick leave, and the Thrift Savings Plan (401K equivalent).
How to Apply
Interested applicants should submit:
• A letter of interest that includes a career synopsis;
• A current curriculum vitae and complete bibliography;
• A diversity statement describing your track record of and commitment to promoting diversity, equity, and inclusion in biomedical research and/or medicine, including, but not limited to, the understanding of and impacting issues of equity, inclusion, and diversity, successful recruitment and/or mentorship of individuals from historically underrepresented groups, demonstrated sustained efforts to promote diversity, equity and inclusion, and plans for addressing diversity and inclusion in the future. (500-word limit)
Applications must be submitted to: https://service.cancer.gov/ccr-careers. E-mailed or paper applications will not be accepted. Initial review of applications is anticipated to begin on or about March 13, 2023, but applications will be accepted until the position is filled. Applications will be treated as confidential. For more information, contact Patrick Miller, Faculty Recruitment Coordinator at millerp@mail.nih.gov.
NIH provides reasonable accommodations to applicants with disabilities. If you require reasonable accommodation during any part of the application and hiring process, please notify us. The decision on granting reasonable accommodation will be made on a case-by-case basis.
The NCI and the CCR are deeply committed to diversity of thought, equity, and inclusion and encourage applications from qualified women, under-represented minorities, and individuals with disabilities.
The DHHS, NIH and NCI are Equal Opportunity Employers Show more details...
via Frederick National Laboratory Talent Network - CareerArc
posted_at: 20 days agoschedule_type: Full-time
PROGRAM DESCRIPTION
The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community. A major focus of the CRTP is the NCI RAS Initiative with the goal to discover new... therapeutic interventions against RAS-driven cancers.
PROGRAM DESCRIPTION
The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community. A major focus of the CRTP is the NCI RAS Initiative with the goal to discover new... therapeutic interventions against RAS-driven cancers. In addition, the CRTP hosts the Nanotechnology Characterization Laboratory (NCL) which performs and standardizes preclinical efficacy and toxicity testing of nanoparticles intended for cancer therapeutics and diagnostics, and the Antibody Characterization Lab (ACL) which characterizes monoclonal antibodies or other renewable affinity binding reagents for use in cancer related research. CRTP scientists also work collaboratively with intramural NCI investigators to provide research technologies and expertise.
The Nanotechnology Characterization Lab (NCL) serves as a national resource and knowledge base for all cancer researchers to facilitate the regulatory review of nanotechnologies intended for cancer therapies and diagnostics. By providing the critical infrastructure and characterization services to nanomaterial providers, the NCL accelerates the transition of basic nanoscale particles and devices into clinical applications.
KEY ROLES/RESPONSIBILITIES
• The Nanotechnology Characterization Lab (NCL) provides nanotechnology characterization services for universities and the pharmaceutical industry (http://ncl.cancer.gov). This position will provide bioanalytical support for NCL's pharmaceutical customers.
• He/she will assist in analytical characterization and development of new bioanalytical methods for evaluating nanomedicines.
• Responsibilities include preparation of biological samples from pharmacokinetic and drug metabolism studies, and analysis by mass spectrometry.
BASIC QUALIFICATIONS
To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:
• Bachelors degree from an accredited college and university according to the Council for Higher Education Accreditation (CHEA) in pharmaceutical science, chemistry, biochemistry, biology or related discipline.
• Foreign degrees must be evaluated for US equivalency.
• In addition to the education requirement, minimum five (5) years related experience.
• Demonstrated background in analytical and/or bioanalytical chemistry
• Experience with preparation of biological samples for quantification of small molecule drugs, including methods, such as HPLC, LC-MS/MS, LLE, SPE.
• Experience analyzing, preparing, and summarizing analytical data.
• Ability to obtain and maintain a security clearance.
PREFERRED QUALIFICATIONS
Candidates with these desired skills will be given preferential consideration:
• Familiarity with drug development and the pharmaceutical industry.
• Demonstrated analytical problem-solving skills.
• Ability to multi-task and work with a diverse research group.
• Excellent coordination and communication skills.
• Some knowledge of drug metabolism-pharmacokinetics (DMPK).
• Ability to work independently in a cross-disciplinary setting.
JOB HAZARDS
• This position is subject to working with or have potential for exposure to animal(s) and/or animal material(s).
• This position is subject to working with or have potential for exposure to infectious material, requiring medical clearance and immunizations.
• This position is subject to working with radioactive material and requires to become an approved radiation worker Show more details...
The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community. A major focus of the CRTP is the NCI RAS Initiative with the goal to discover new... therapeutic interventions against RAS-driven cancers. In addition, the CRTP hosts the Nanotechnology Characterization Laboratory (NCL) which performs and standardizes preclinical efficacy and toxicity testing of nanoparticles intended for cancer therapeutics and diagnostics, and the Antibody Characterization Lab (ACL) which characterizes monoclonal antibodies or other renewable affinity binding reagents for use in cancer related research. CRTP scientists also work collaboratively with intramural NCI investigators to provide research technologies and expertise.
The Nanotechnology Characterization Lab (NCL) serves as a national resource and knowledge base for all cancer researchers to facilitate the regulatory review of nanotechnologies intended for cancer therapies and diagnostics. By providing the critical infrastructure and characterization services to nanomaterial providers, the NCL accelerates the transition of basic nanoscale particles and devices into clinical applications.
KEY ROLES/RESPONSIBILITIES
• The Nanotechnology Characterization Lab (NCL) provides nanotechnology characterization services for universities and the pharmaceutical industry (http://ncl.cancer.gov). This position will provide bioanalytical support for NCL's pharmaceutical customers.
• He/she will assist in analytical characterization and development of new bioanalytical methods for evaluating nanomedicines.
• Responsibilities include preparation of biological samples from pharmacokinetic and drug metabolism studies, and analysis by mass spectrometry.
BASIC QUALIFICATIONS
To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:
• Bachelors degree from an accredited college and university according to the Council for Higher Education Accreditation (CHEA) in pharmaceutical science, chemistry, biochemistry, biology or related discipline.
• Foreign degrees must be evaluated for US equivalency.
• In addition to the education requirement, minimum five (5) years related experience.
• Demonstrated background in analytical and/or bioanalytical chemistry
• Experience with preparation of biological samples for quantification of small molecule drugs, including methods, such as HPLC, LC-MS/MS, LLE, SPE.
• Experience analyzing, preparing, and summarizing analytical data.
• Ability to obtain and maintain a security clearance.
PREFERRED QUALIFICATIONS
Candidates with these desired skills will be given preferential consideration:
• Familiarity with drug development and the pharmaceutical industry.
• Demonstrated analytical problem-solving skills.
• Ability to multi-task and work with a diverse research group.
• Excellent coordination and communication skills.
• Some knowledge of drug metabolism-pharmacokinetics (DMPK).
• Ability to work independently in a cross-disciplinary setting.
JOB HAZARDS
• This position is subject to working with or have potential for exposure to animal(s) and/or animal material(s).
• This position is subject to working with or have potential for exposure to infectious material, requiring medical clearance and immunizations.
• This position is subject to working with radioactive material and requires to become an approved radiation worker Show more details...
via The Lancet Careers
schedule_type: Full-time
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI...
Division of Cancer Treatment and Diagnosis (DCTD)
Cancer Therapy Evaluation Program (CTEP)
Position Description:
The Division of Cancer Treatment and Diagnosis (DCTD), National Cancer Institute (NCI), is seeking Physicians to fill vacancies in the Developmental Therapeutics Clinic (DTC), Office of the Director (OD), Clinical Investigations
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI...
Division of Cancer Treatment and Diagnosis (DCTD)
Cancer Therapy Evaluation Program (CTEP)
Position Description:
The Division of Cancer Treatment and Diagnosis (DCTD), National Cancer Institute (NCI), is seeking Physicians to fill vacancies in the Developmental Therapeutics Clinic (DTC), Office of the Director (OD), Clinical Investigations Branch (CIB) and Investigational Drug Branch (IDB) in Cancer Therapy Evaluation Program (CTEP).
The Division of Cancer Treatment and Diagnosis (DCTD) takes prospective detection and treatment leads, facilitates their paths to clinical application, and expedites the initial and subsequent large-scale testing of new agents, biomarkers, imaging tests, and other therapeutic interventions (radiation, surgery, immunotherapy) in patients. The DCTD has nine major programs that work together to bring unique molecules, diagnostic tests, and therapeutic interventions from the laboratory bench research to the patient bedside.
The mission of the Cancer Therapy Evaluation Program (CTEP) is to improve the lives of cancer patients by finding better ways to treat, control and cure cancer. The CTEP accomplishes this mission by funding an extensive national program of cancer research and by sponsoring clinical trials to evaluate new anti-cancer agents, with a particular emphasis on translational research to elucidate molecular targets and mechanisms of drug effects.
The Clinical Investigations Branch (CIB) implements and oversees adult and pediatric cancer clinical trials portfolios, focusing on the incorporation of new molecular characterization and novel therapeutic strategies into clinical trials for both adults and children with cancer.
The Investigational Drug Branch (IDB) oversees a large portfolio of novel cancer agents in an innovative investigational experimental therapeutics program.
The goal of the NCI Developmental Therapeutics Clinic (DTC) in the Office of the Director (OD) is to develop new treatments for patients with advanced cancer through novel early phase clinical trials. Each year patients from around the world with cancers that have relapsed after standard treatment visited the DTC for consultation about participation in early phase treatment trials conducted at the NIH. The DTC participates in the Experimental Therapeutics Clinical Trials Network (ETCN) and supports the work of DCTD.
Qualifications:
Applicants must be U.S. citizens. These are full-time Federal Government positions, located in Bethesda and Rockville, Maryland. Compensation for these positions is commensurate with the individual’s qualifications and experience, as permitted with Federal Government appointments.
How to Apply:
This is an exploratory ad to gauge interest and a possible candidate pool. The vacancy announcements to fill these positions will be posted on: usajobs.gov at a later date.
Interested candidates:
You may contact the following individuals for additional information:
IDB: contact Dr. Jeffrey A. Moscow jeffrey.moscow@nih.gov
CIB: contact Dr. Malcolm Smith Malcolm.Smith@nih.gov
OD: contact Dr. Alice Chen Alice.Chen@nih.gov
The NIH and NCI are dedicated to building a diverse community in its training and employment programs and encourages the application and nomination of qualified women, minorities, and individuals with disabilities.
HHS, NIH, and NCI are Equal Opportunity Employers Show more details...
National Institutes of Health (NIH)
National Cancer Institute (NCI...
Division of Cancer Treatment and Diagnosis (DCTD)
Cancer Therapy Evaluation Program (CTEP)
Position Description:
The Division of Cancer Treatment and Diagnosis (DCTD), National Cancer Institute (NCI), is seeking Physicians to fill vacancies in the Developmental Therapeutics Clinic (DTC), Office of the Director (OD), Clinical Investigations Branch (CIB) and Investigational Drug Branch (IDB) in Cancer Therapy Evaluation Program (CTEP).
The Division of Cancer Treatment and Diagnosis (DCTD) takes prospective detection and treatment leads, facilitates their paths to clinical application, and expedites the initial and subsequent large-scale testing of new agents, biomarkers, imaging tests, and other therapeutic interventions (radiation, surgery, immunotherapy) in patients. The DCTD has nine major programs that work together to bring unique molecules, diagnostic tests, and therapeutic interventions from the laboratory bench research to the patient bedside.
The mission of the Cancer Therapy Evaluation Program (CTEP) is to improve the lives of cancer patients by finding better ways to treat, control and cure cancer. The CTEP accomplishes this mission by funding an extensive national program of cancer research and by sponsoring clinical trials to evaluate new anti-cancer agents, with a particular emphasis on translational research to elucidate molecular targets and mechanisms of drug effects.
The Clinical Investigations Branch (CIB) implements and oversees adult and pediatric cancer clinical trials portfolios, focusing on the incorporation of new molecular characterization and novel therapeutic strategies into clinical trials for both adults and children with cancer.
The Investigational Drug Branch (IDB) oversees a large portfolio of novel cancer agents in an innovative investigational experimental therapeutics program.
The goal of the NCI Developmental Therapeutics Clinic (DTC) in the Office of the Director (OD) is to develop new treatments for patients with advanced cancer through novel early phase clinical trials. Each year patients from around the world with cancers that have relapsed after standard treatment visited the DTC for consultation about participation in early phase treatment trials conducted at the NIH. The DTC participates in the Experimental Therapeutics Clinical Trials Network (ETCN) and supports the work of DCTD.
Qualifications:
Applicants must be U.S. citizens. These are full-time Federal Government positions, located in Bethesda and Rockville, Maryland. Compensation for these positions is commensurate with the individual’s qualifications and experience, as permitted with Federal Government appointments.
How to Apply:
This is an exploratory ad to gauge interest and a possible candidate pool. The vacancy announcements to fill these positions will be posted on: usajobs.gov at a later date.
Interested candidates:
You may contact the following individuals for additional information:
IDB: contact Dr. Jeffrey A. Moscow jeffrey.moscow@nih.gov
CIB: contact Dr. Malcolm Smith Malcolm.Smith@nih.gov
OD: contact Dr. Alice Chen Alice.Chen@nih.gov
The NIH and NCI are dedicated to building a diverse community in its training and employment programs and encourages the application and nomination of qualified women, minorities, and individuals with disabilities.
HHS, NIH, and NCI are Equal Opportunity Employers Show more details...
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