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Tmz meaning medical

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What is trimetazidine (TMZ) used for? Trimetazidine (TMZ) is a medication used to treat heart-related conditions like angina. It helps metabolize fatty acids, which helps your body use oxygen. The drug allows for more blood flow to your heart and limits quick changes in your blood pressure. This can help lessen chest pain from blocked blood vessels.
Can TMZ be used to treat brain tumors? The positive data obtained in a large phase III clinical trial [ 110] prompted the FDA to recommend TMZ as a first-line drug for the treatment of newly diagnosed brain tumors in 2005. More recently, the use of TMZ for the treatment of a variety of solid tumors -in addition to nervous system tumors- is under investigation in a number
Is TMZ a chemotherapeutic? TMZ is part of the larger class of DNA alkylating agents that were first discovered to have anti-tumorigenic effects in the 1940s and quickly became the first drugs to be used as chemotherapeutics.
Is TMZ antitumoral? Probably counterintuitively, antitumoral activity of TMZ requires a functional DNA mismatch repair (MMR) of the tumor cell and is mediated by the lower frequent O 6 -methylguanine lesions [ 33, 40 ]. O 6 -methylguanine is mispairing with thymine, which is recognized by the MMR machinery [ 39, 40 ].
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Temozolomide - Wikipedia
Temozolomide, sold under the brand name Temodar among others, is an anticancer medication used to treat brain tumors such as glioblastoma and anaplastic astrocytoma. It is taken by mouth or via intravenous infusion. The most common side effects with...
https://en.wikipedia.org/wiki/Temozolomide
Temozolomide FAQs | UCSF Brain Tumor Center
Temozolomide (TMZ) is an chemotherapy pill that also goes by the brand names Temodar and Temodal. Approved for use in the United States since 1999, TMZ is part of standard treatment for patients with gliomas. TMZ is administered alone, or in combination...
https://braintumorcenter.ucsf.edu/treatments/medical-therapy/temozolomide-faqs
Temozolomide and Other Alkylating Agents in Glioblastoma Therapy
The alkylating agent temozolomide (TMZ) together with maximal safe bulk resection and focal radiotherapy comprises the standard treatment for glioblastoma (GB), a particularly aggressive and lethal primary brain tumor. GB affects 3.2 in 100,000 people...
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783999/
Temozolomide: An Updated Overview of Resistance Mechanisms ...
Temozolomide (TMZ), an oral alkylating prodrug which delivers a methyl group to purine bases of DNA (O6-guanine; N7-guanine and N3-adenine), is frequently used together with radiotherapy as part of the first-line treatment of high-grade gliomas.
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8206461/
Temozolomide - NCI - National Cancer Institute
This page contains brief information about temozolomide and a collection of links to more information about the use of this drug, research results, and ongoing clinical trials.
https://www.cancer.gov/about-cancer/treatment/drugs/temozolomide
Temozolomide treatment outcomes and immunotherapy efficacy …
Temozolomide (TMZ) is used in standard of care in patients to reduce tumor burden by directly killing proliferating tumor cells. This drug may also induce mutations in surviving tumor cells and eradicate some proliferating immune cells, which could...
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9833842/
Temozolomide | The Brain Tumour Charity
Short summary. Sometimes called TMZ, temozolomide is a chemotherapy drug that is sometimes used for glioblastoma and astrocytoma brain tumours. It is usually taken as a pill with food and is often given alongside radiotherapy. On this page, we’ll cover:...
https://www.thebraintumourcharity.org/brain-tumour-diagnosis-treatment/treating-brain-tumours/adult-...
Temozolomide (Temodal) | Cancer information | Cancer …
Temozolomide is a type of chemotherapy. It is also known as Temodal. It is a treatment for: certain types of brain tumour such as glioblastoma and astrocytoma. neuroendocrine tumours. adrenal gland cancer. You pronounce temozolomide as...
https://www.cancerresearchuk.org/about-cancer/treatment/drugs/temozolomide
Temozolomide - an overview | ScienceDirect Topics
Temozolomide (TMZ) is a small lipophilic alkylating agent in use as an anticancer agent for high-grade, aggressive brain tumors and melanoma. The action of TMZ depends on its ability to alkylate DNA, leading to DNA damage and tumor cell death. Malignant...
https://www.sciencedirect.com/topics/medicine-and-dentistry/temozolomide
Temozolomide: mechanisms of action, repair and resistance
Glioblastoma multiforme is the most common aggressive adult primary tumour of the central nervous system. Treatment includes surgery, radiotherapy and adjuvant temozolomide (TMZ) chemotherapy. TMZ is an alkylating agent prodrug, delivering a methyl...
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https://pubmed.ncbi.nlm.nih.gov/22122467/
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Temozolomide